Folic acid (folate) is a kind of B vitamin. Children and adults both require folate to produce healthy red blood cells. Zinc is included in most daily vitamin and mineral supplements. Zinc was known as a protective agent of the skin and its cells. Wound healing is a continuous process where the skin repairs itself after injury. In our study, our aim was to explore the possible effect of zinc on wound healing via fibroblast cells. Gingival fibroblasts were used for wound-healing assay with the use of folic acid and zinc in the dosages of 1 mM, 10 uM and 100 uM. Real time PCR analyses were done after RNA isolation and c DNA synthesis from cell culture. According to wound healing assay results, folic acid’s effectiveness on fibroblastic activity and cell migration was limited. Beside these, zinc’s effectiveness on fibroblastic activity and cell migration was fast and regular. Due to gene expression analyses, there was an upregulatory effect of folic acid on genes which are important for wound healing. There was an upregulatory effect of zinc with the dosages of 1 mM and 100 uM on these genes either. Due to our results, unfortunately we can say, folic acid is not enough for topical usage on wound healing. But fortunately we can say zinc’s wound healing effect can be used for many cosmetical areas.
Zehra Dilsad COBAN et al, 2016. Zinc can be a local wound healing agent but folic acid?. International Journal of Current Science and Technology. Vol.4, Issue, 11, pp.286-290.